What is CPIC?The Clinical Pharmacogenetics Implementation Consortium (CPIC) was formed as a shared project between PharmGKB and the Pharmacogenomics Research Network (PGRN). CPIC guidelines are peer-reviewed and published in a leading journal (in partnership with Clinical Pharmacology and Therapeutics) with simultaneous posting to PharmGKB with supplemental information/data and updates. Anyone with clinical interests in pharmacogenetics is eligible for membership. CPIC’s goal is to address some of the barriers to implementation of pharmacogenetic tests into clinical practice.
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BackgroundOne barrier to clinical implementation of pharmacogenetics is the lack of freely available, peer-reviewed, updatable, and detailed gene/drug clinical practice guidelines. CPIC provides guidelines that enable the translation of genetic laboratory test results into actionable prescribing decisions for specific drugs. The guidelines can center on genes (e.g. thiopurine methyltransferase and its implications for thiopurines) or around drugs (e.g. warfarin and CYP2C9 and VKORC1). Priority is given to genotyping tests that are already offered in CLIA-approved clinical settings.
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Mary V. Relling, Pharm.D.
Chair, Pharmaceutical Dept. St. Jude Children's Research Hospital 262 Danny Thomas Place, Room I-5112 Memphis, TN 38105 ph 901 595 2348 fax 901 595 8869 cell 901 428 6903 [email protected] |
Teri E. Klein, PhD
Stanford University School of Medicine 443 Via Ortega, Room 213 BioE Altman Lab MC:4245 Stanford, CA 94305 ph 650 736 0156 fax 650 725 3863 [email protected] |
Steering Committee: |
Scientific Advisory Board: |
Mary V. Relling, Pharm.D. St. Jude Children’s Research Hospital, Memphis
Teri E. Klein, Ph.D. Stanford University Julie A. Johnson, Pharm.D. University of Florida Dan M. Roden, M.D. Vanderbilt University Rachel F. Tyndale, Ph.D. University of Toronto and CAMH |
Gwendolyn A. McMillin, Ph.D. ARUP Laboratories
John David Nolan, M.D., Ph.D., Cerner Robert Nussbaum, M.D. University of California, San Francisco Heidi Rehm, Ph.D. Partners Healthcare Marc S. Williams, M.D. Geisinger Brad Strock, Epic |